中国学者发现LINC00978可预测乳腺癌患者不良预后

发表于 讨论求助 2021-10-07 12:26:24



  长链非编码核糖核酸(lncRNA)指的是长于200核苷酸、不编码蛋白质的转录物,在人类基因组中涉及乳腺癌的发生和发展。


  2016年11月29日,英国《自然》旗下《科学报告》在线发表复旦大学(上海医学院)附属肿瘤医院、南昌大学第二附属医院、肿瘤医学协同创新中心邓玲玲、迟亚云、刘磊、黄乃思、王琳、吴炅等学者的研究报告,发现乳腺癌细胞系和组织中有一种lncRNA——LINC00978高表达。


  此外,在对195例乳腺癌患者开展的研究中,LINC00978表达与激素受体水平成负相关(P=0.033)。生存曲线(Kaplan-Meier)分析显示,LINC00978高表达患者与LINC00978低表达患者相比,无病生存显著较差(P=0.012),并且多变量分析确定LINC00978为乳腺癌独立预后因素(P=0.008,风险比=2.270,95%置信区间:1.237~4.165)。


  该研究表明,LINC00978可能是乳腺癌的癌基因,可以作为预测乳腺癌患者预后的潜在生物标志物。


Sci Rep. 2016 Nov 29;6:37936.


LINC00978 predicts poor prognosis in breast cancer patients.


Deng LL, Chi YY, Liu L, Huang NS, Wang L, Wu J.


Fudan University Shanghai Cancer Center, 200032, China; Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China; Fudan University, Shanghai Medical College, Shanghai, 200032, China; Collaborative Innovation Center for Cancer Medicine, China.


Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs in the human genome that involves in breast cancer development and progression. Here, we identify a lncRNA, LINC00978, which is upregulated in breast cancer cell lines and tissues compared with corresponding controls. Furthermore, LINC00978 expression is negatively associated with hormone receptor (HR) status in 195 breast cancer patients studied (p = 0.033). Kaplan-Meier survival analysis shows that patients with high LINC00978 expression have poorer disease-free survival (DFS) than those with low LINC00978 expression (p = 0.012), and multivariate analysis identifies LINC00978 as an independent prognostic factor in breast cancer (p = 0.008, hazard ratio [HR] = 2.270, 95% confidence interval [CI] 1.237-4.165). Our study indicates that LINC00978 may be an oncogene in breast cancer, and can serve as a potential biomarker to predict prognosis in breast cancer patients.


PMID: 27897214


DOI: 10.1038/srep37936





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